Abstract: We used site-level methane (CH₄) emissions data from over 1,000 natural gas (NG) production sites in eight basins, including 92 new site-level CH₄ measurements in the Uinta, northeastern Marcellus, and Denver-Julesburg basins, to investigate CH₄ emissions characteristics and develop a new national CH₄ emission estimate for the NG production sector. The distribution of site-level emissions is highly skewed, with the top 5% of sites accounting for 50% of cumulative emissions. High emitting sites are predominantly also high producing (>10 Mcfd). However, low NG production sites emit a comparably larger fraction of their CH₄ production. When combined with activity data, we predict that this creates substantial variability in the basin-level CH4 emissions which, as a fraction of basin-level CH4 production, range from 0.90% for the Appalachian and Greater Green River to > 4.5% in the San Juan and San Joaquin. This suggests that much of the basin-level differences in production-normalized emissions reported by aircraft studies can be explained by differences in site size and distribution of site-level production rates. We estimate that NG production sites emit total CH₄ emissions of 830 Mg/h (95% CI: 530—1,200), 63% of which come from the sites producing <100 Mcfd that account for only 10% of total NG production. Our total CH₄ emissions estimate is 2.3 times higher than the U.S. EPA’s estimate and likely attributable to the disproportionate influence of high emitting sites.